NEURO
HOME PAGE FACULTY COURSES RESEARCH
and GRANTS INFO
for STUDENTS
KECK
GRANT (Neuroscience
and the Humanities)
|
Ann M. Kleinschmidt
Associate Professor of Biology
Mailing Address:
Biology Dept., Allegheny College
Meadville PA 16335
Phone: 814-332-2366
Fax: 814-332-2789
E-mail: akleinsc@allegheny.edu
Office: Biology 219
Ann's
Home Page
|
|
Ann received a B.S. in Biochemistry from the University of Wisconsin,
Madison, a Ph.D. from the University of California, Los Angeles, and
conducted postdoctoral research at the University of Minnesota, St.
Paul, Botany Department, and the Worcester Foundation for Experimental
Biology, Cell Biology Group. Ann teaches Molecular Biology, Current
topics in Gene Regulation, Introductory Biology, and a non-majors Biotechnology
course.
Ann's general research interests are in the molecular and genetic basis
of gene regulation and is currently conducting research on the cell
and developmental specific expression of the von Willebrand Factor gene.
This gene is specifically expressed in endothelial cells which comprise
the vascular system. The protein product of this gene is one of the
major players in the initial steps of wound healing and defects in the
expression of this gene or in the protein product comprise the major
cause of bleeding disorders world wide. Ann is currently doing research
to elucidate the components required for the appropriate expression
of the vWF gene in normal endothelial cells. Future research goals are
to understand the difference between the chromosomal structure of the
gene in expressing versus non-expressing tissue and to determine what
cues are responsible for appropriate expression of this gene during
development. Student researchers in her lab conduct studies to understand
what role particular regions of the vWF gene play in the appropriate
expression of this gene as well as defining sequences responsible for
appropriate expression. Ann also has an interest in the ethics of the
human genome project and in developing educational programs to educate
the general public in the implications of genetic testing. While not
teaching or doing research Ann enjoys gardening, bird watching, kayaking,
rollerblading, singing (though she sometimes does this while doing research),
and cross-stitching.
